Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography: implications for clinical practice
G Kristo, A Leemans, B de Gelder, M Raemaekers… - European …, 2013 - Springer
European radiology, 2013•Springer
Objectives To assess the reliability of diffusion tensor imaging (DTI)-based fibre tractography
(FT), which is a prerequisite for clinical applications of this technique. Here we assess the
test–retest reproducibility of the architectural and microstructural features of two clinically
relevant tracts reconstructed with DTI-FT. Methods The corticospinal tract (CST), arcuate
fasciculus (AF) and its long segment (AF l) were reconstructed in 17 healthy subjects imaged
twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract …
(FT), which is a prerequisite for clinical applications of this technique. Here we assess the
test–retest reproducibility of the architectural and microstructural features of two clinically
relevant tracts reconstructed with DTI-FT. Methods The corticospinal tract (CST), arcuate
fasciculus (AF) and its long segment (AF l) were reconstructed in 17 healthy subjects imaged
twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract …
Objectives
To assess the reliability of diffusion tensor imaging (DTI)-based fibre tractography (FT), which is a prerequisite for clinical applications of this technique. Here we assess the test–retest reproducibility of the architectural and microstructural features of two clinically relevant tracts reconstructed with DTI-FT.
Methods
The corticospinal tract (CST), arcuate fasciculus (AF) and its long segment (AFl) were reconstructed in 17 healthy subjects imaged twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract values were used to assess the microstructural reproducibility. Spatial correlation and fibre overlap were used to assess the architectural reproducibility.
Results
Spatial correlation was 68 % for the CST and AF, and 69 % for the AFl. Overlap was 69 % for the CST, 61 % for the AF, and 59 % for the AFl. This was comparable to 2-mm tract shift variability. CVs of diffusion-derived tract values were at most 3.4 %.
Conclusions
The results showed low architectural and microstructural variability for the reconstruction of the tracts. The architectural reproducibility results encourage the further investigation of the use of DTI-FT for neurosurgical planning. The high microstructural reproducibility results are promising for using DTI-FT in neurology to assess or predict functional recovery.
Key Points
• Magnetic resonance diffusion tensor fibre tractography is increasingly used in the neurosciences.
• The architectural reproducibility of fibre pathways can be up to 69 %.
• However the microstructural variability of fibre pathways is only 3.4 % at most.
• The architectural reproducibility results encourage the use of DTI-FT for neurosurgery.
• The microstructural reproducibility results support the use of DTI-FT in neurology.
Springer
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